Vaginal seeding and the microbiome – bloom or bust?
My kids’ pediatrician meets with prospective new patient families during their pregnancy. A few weeks ago a woman asked: “what do you think about me wiping my vagina with a cloth and spreading it all over my baby’s mouth”. He knew she was talking about vaginal seeding but was surprised by the bluntness of her description (I mean, come on, he’s a pediatrician) and didn’t exactly know how to answer. He remembers saying something like “ummmmm, that’s not usually a good idea”
My son’s appointment was the next day so he knew he had the perfect audience for this story and the perfect opportunity to discuss it. He wanted to know how often this is actually happening in the delivery room (as a general pediatrician he isn’t at deliveries) and what exactly did happen during the vaginal seeding process. And finally, what is the best way to answer that question?
People have taken ahold of this concept and essentially “advertised” it to women as a good option to help expose baby to the benefits of the vaginal microbiome bacteria if she has to have a c-section. According to one of my patients, “everyone” has told her this is “now common practice”.
Is this the whole truth? Is it a good alternative? Is it safe? Is everyone doing it? Or are we better off without ever knowing this was a thing?
Technically, it’s inoculating a cotton gauze / pad / swab with vaginal fluids to transfer the vaginal flora to the mouth, nose, or skin of a newborn baby. Or, “wiping my vagina with a cloth and spreading it all over my baby’s mouth”.
We know breastfeeding and skin to skin contact immediately after delivery help establish a newborn’s microbiome through colonization of different types of bacteria. The vaginal microbiome probably plays a huge role for those babies exposed to the vagina during labor.
And it worked. The babies exposed to the vaginal fluid after c-section had similar microbiota as those babies born vaginally. And differed from those babies born via cesarean and not exposed to maternal vaginal fluid.
These results provided a lot of optimism for women who needed c-section and were worried about the microbiome exposure.
This was the study protocol: a wet gauze pad was placed in the vagina an hour before the c-section. Right before the c-section started, the gauze was removed. When the baby was born (within the first minute), the baby was swabbed with the gauze pad. First lips, then face, chest, arms, legs, genitals and anal region, then back. All the swabbing happened in about 15 seconds.
Yes, I agree, it sounds great. The benefits – these are all potential at this point. The study followed babies for the first 30 days of life. And a different study showed that babies born via vaginal delivery versus c-section had the same microbiota at 6 months of life without the vaginal seeding, so we’re not sure if there would be a difference looking at these babies long term. The labor and delivery process is extraordinarily complex and isn’t completely understood. To say the only difference between a vaginal delivery and a c-section is the exposure to the vaginal microbiome is oversimplification. To say the way to restore a microbiome is by swabbing a baby with an inoculated gauze pad is oversimplification. Also, there were only 4 babies studied. We never (or should never) take 4 individual outcomes and apply it to the general population.
The women in the study had negative STD panel, negative GBS, no signs of vaginosis or viral infections, and a vaginal pH <4.5 immediately before the process started. This isn’t a standard check for all pregnant women. A woman with an undiagnosed infection (say, genital herpes, which can be asymptomatic in up to 25% of women who carry the virus) may inoculate their newborn baby with herpes. This kind of exposure can be lethal (so much so that we don’t want women laboring if they have a herpes outbreak, and we give medication to prevent outbreaks and limit viral shedding weeks before anticipated delivery).
So bottom line for me: I see a lot of potential here. So did the authors, apparently, because a little side note at the bottom of the study reports a submitted US patent application.
But as of now, those benefits may only be temporary, and the associated risks could be damaging and / or permanent and / or catastrophic. Instead, I’m advocating for reducing overall rate of c-sections when possible and safe. And when c-sections are recommended and necessary, I’m loving the “gentle cesarean” – direct skin contact between mom and baby immediately after delivery.
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